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Participants were male and female adults aged 18 years who were of non-childbearing potential and met the BMI inclusion criteria of either 30.0 kg/m, or 27.0 kg/m with hypertension or dyslipidemia

Regulatory status (US) Not FDA-approved Category 2 (2023) PCAC July 2026 Compound Melatonin What it is Hormone supplement Mechanism (in plain English) Shifts sleep timing via the circadian system

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Weight regulation : In mouse studies, systemic administration produced a progressive reduction in body weight and up to a ~35% decrease in white adipose tissue mass